PROTAC Sirt2 Degrader-1

Catalog No. Size PriceQuantity
M7989-2 2mg solid $525
M7989-10 10mg solid $2,100


Sirt2-PROTAC-1 is a SirReal based PROTAC, inducing isotype-selective Sirt2 degradation. PROTAC Sirt2 Degrader-1 is composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).

Product information

CAS Number: 2098487-75-1

Molecular Weight: 852.94

Formula: C40H40N10O8S2

Chemical Name: N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide



InChi: InChI=1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells

Products are for research use only. Not for human use.

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