PROTAC RIPK degrader-6


Catalog No. Size PriceQuantity
M8002-2 2mg solid $330
M8002-10 10mg solid $1,320

Description

PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder.

Product information

CAS Number: 2089205-64-9

Molecular Weight: 889.00

Formula: C43H48N6O11S2

Chemical Name: 14-({4-[(1, 3-benzothiazol-5-yl)amino]-6-(2-methylpropane-2-sulfonyl)quinolin-7-yl}oxy)-N-[2-(2, 6-dioxopiperidin-3-yl)-1-oxo-2, 3-dihydro-1H-isoindol-4-yl]-3, 6, 9, 12-tetraoxatetradecanamide

Smiles: CC(C)(C)S(=O)(=O)C1=CC2C(C=C1OCCOCCOCCOCCOCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)=NC=CC=2NC1C=C2N=CSC2=CC=1

InChiKey: BRZGXSNAXRPPFI-UHFFFAOYSA-N

InChi: InChI=1S/C43H48N6O11S2/c1-43(2,3)62(54,55)38-22-29-32(46-27-7-9-37-34(21-27)45-26-61-37)11-12-44-33(29)23-36(38)60-20-19-58-16-15-56-13-14-57-17-18-59-25-40(51)47-31-6-4-5-28-30(31)24-49(42(28)53)35-8-10-39(50)48-41(35)52/h4-7,9,11-12,21-23,26,35H,8,10,13-20,24-25H2,1-3H3,(H,44,46)(H,47,51)(H,48,50,52)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (112.49 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation

References:

  1. John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.

Products are for research use only. Not for human use.

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