HLI 373 dihydrochloride

Catalog No. Size PriceQuantity
M8040-2 2mg solid $145
M8040-10 10mg solid $435


HLI-373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53. HLI-373 induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Product information

CAS Number: 1782531-99-0

Molecular Weight: 414.33

Formula: C18H25Cl2N5O2

Chemical Name: 5-((3-(dimethylamino)propyl)amino)-3, 10-dimethylpyrimido[4, 5-b]quinoline-2, 4(3H, 10H)-dione dihydrochloride

Smiles: Cl.Cl.CN(C)CCCNC1=C2C(=NC(=O)N(C)C2=O)N(C)C2=CC=CC=C21


InChi: InChI=1S/C18H23N5O2.2ClH/c1-21(2)11-7-10-19-15-12-8-5-6-9-13(12)22(3)16-14(15)17(24)23(4)18(25)20-16;;/h5-6,8-9,19H,7,10-11H2,1-4H3;2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7(8):2445-54.
  2. Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40.
  3. Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117(8):1192-1201.

Products are for research use only. Not for human use.

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