Nimbolide


Catalog No. Size PriceQuantity
M8042-2 2mg solid $345
M8042-10 10mg solid $1,380

Description

Nimbolide is a natural inhibitor of pancreatic cancer growth and metastasis through ROS-mediated apoptosis. It inhibits epithelial-to-mesenchymal transition.

Product information

CAS Number: 25990-37-8

Molecular Weight: 466.52

Formula: C27H30O7

Chemical Name: 8(R)-(3-Furanyl)-2aR, 5aR, 6S, 6aR, 8R, 9, 9aR, 10aS, 10bR, 10cR-decahydro-2a, 5a, 6a, 7-tetramethyl-2, 5-dioxo-2H, 5H-cyclopenta[d']naphtho[1, 8-bc:2, 3-b']difuran-6-acetic acid, methyl ester

Smiles: CC1[C@@H](C[C@H]2O[C@@H]3[C@@H]4OC(=O)[C@]5(C)C=CC(=O)[C@@](C)([C@H]54)[C@@H](CC(=O)OC)[C@]3(C)C=12)C1=COC=C1

InChiKey: JZIQWNPPBKFOPT-LSYMHUITSA-N

InChi: InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3/t15-,16-,17-,21-,22+,23-,25-,26+,27-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28(5):1026-35.

Products are for research use only. Not for human use.

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