Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation.
CAS Number: 380315-80-0
Molecular Weight: 369.48
Chemical Name: N -[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1, 1-dimethylethyl)benzamide
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 74 mg/mL(200.28 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
- Marcus J G W Ladds, et al. J Biol Chem . 2020 Sep 8;jbc.RA119.012056.
- Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.
Products are for research use only. Not for human use.
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