Tenovin-1

Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation.

Product information

CAS Number: 380315-80-0

Molecular Weight: 369.48

Formula: C20H23N3O2S

Chemical Name: N -[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1, 1-dimethylethyl)benzamide

Smiles: CC(=O)NC1C=CC(=CC=1)NC(=S)NC(=O)C1C=CC(=CC=1)C(C)(C)C

InChiKey: WOWJIWFCOPZFGV-UHFFFAOYSA-N

InChi: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 74 mg/mL(200.28 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.

In Vivo:

Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.

References:

1. Marcus J G W Ladds, et al. J Biol Chem . 2020 Sep 8;jbc.RA119.012056.
2. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

Products are for research use only. Not for human use.