Catalog No. Size PriceQuantity
M8051-2 2mg solid $90
M8051-10 10mg solid $270


Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation.

Product information

CAS Number: 380315-80-0

Molecular Weight: 369.48

Formula: C20H23N3O2S

Chemical Name: N -[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1, 1-dimethylethyl)benzamide

Smiles: CC(=O)NC1C=CC(=CC=1)NC(=S)NC(=O)C1C=CC(=CC=1)C(C)(C)C


InChi: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 74 mg/mL(200.28 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.

In Vivo:

Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.


  1. Marcus J G W Ladds, et al. J Biol Chem . 2020 Sep 8;jbc.RA119.012056.
  2. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed