10-Deacetyl-7-xylosyl paclitaxel


Catalog No. Size PriceQuantity
M8075-2 Solid 2 mg $90
M8075-10 Solid 10 mg $270

Description

10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T. chinensis. It induces the disassembly of pig brain and Physarum microtubules in cell-free assays. 10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of, as well as induces cell cycle arrest at the G2/M phase and apoptosis in, PC3 prostate cancer cells.

Product information

CAS Number: 90332-63-1

Molecular Weight: 943.98

Formula: C50H57NO17

Chemical Name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-1,12-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-9-{[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate

Smiles: CC1(C)C2[C@@H](O)C(=O)[C@@]3(C)[C@H]([C@H](OC(=O)C4C=CC=CC=4)[C@]1(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C1C=CC=CC=1)C1C=CC=CC=1)C=2C)[C@@]1(CO[C@@H]1C[C@@H]3O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)OC(C)=O

InChiKey: ORKLEZFXASNLFJ-DYLQFHMVSA-N

InChi: InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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