Catalog No. Size PriceQuantity
M8173-2 Solid 2 mg $130
M8173-10 Solid 10 mg $390


QL47, also known as QL-XII-47, is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.

Product information

CAS Number: 1469988-75-7

Molecular Weight: 447.49

Formula: C27H21N5O2


BTK Inhibitor

QL 47


Chemical Name: 9-(1-methyl-1H-pyrazol-4-yl)-1-[1-(prop-2-enoyl)-2,3-dihydro-1H-indol-6-yl]-1H,2H-benzo[h]1,6-naphthyridin-2-one

Smiles: CN1C=C(C=N1)C1=CC2=C3C(C=CC(=O)N3C3=CC4=C(CCN4C(=O)C=C)C=C3)=CN=C2C=C1


InChi: InChI=1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed