Tetrodotoxin is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials.
CAS Number: 4368-28-9
Molecular Weight: 319.27
Chemical Name: (1R,5R,6R,7R,9S,11S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[220.127.116.11⁷,¹¹.0¹,⁶]tetradec-3-ene-5,9,12,13,14-pentol
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
- Bane V, Lehane M, Dikshit M, O'Riordan A, Furey A. Tetrodotoxin: chemistry, toxicity, source, distribution and detection. Toxins (Basel). 2014 Feb 21;6(2):693-755.
- Lee CH, Ruben PC. Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Channels (Austin). 2008 Nov-Dec;2(6):407-12.
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