Genz-123346 free base

Catalog No. Size PriceQuantity
M8323-2 Solid 2 mg $90
M8323-10 Solid 10 mg $270


Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.

Product information

CAS Number: 491833-30-8

Molecular Weight: 418.57

Formula: C24H38N2O4

Chemical Name: N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide



InChi: InChI=1S/C24H38N2O4/c1-2-3-4-5-6-7-10-23(27)25-20(18-26-13-8-9-14-26)24(28)19-11-12-21-22(17-19)30-16-15-29-21/h11-12,17,20,24,28H,2-10,13-16,18H2,1H3,(H,25,27)/t20-,24-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Solubility (25°C) DMSO: 84 mg/mL(200.68 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

In Zucker diabetic fatty rats, treatment with Genz-123346 significantly lowers blood glucose levels and consequently partially prevents the normal deterioration of pancreatic β-cell function over time and preserves the ability of the islets to secrete insulin. In the high-fat-fed diet-induced obese mice, Genz-123346 essentially normalizes A1C levels to that of the lean animals. The improvement in A1C levels is quite persistent, extending >4 months in the diet-induced obese mice.


  1. Zhao H, et al. Diabetes. 2007, 56(5):1210-8.

Products are for research use only. Not for human use.

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