LY2409881 trihydrochloride

LY2409881 is a potent and selective IKK2 inhibitor. LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs.

Product information

CAS Number: 946518-60-1

Molecular Weight: 594.43

Formula: C24H32Cl4N6OS

Synonym:

LY-2409881 trihydrochloride

Chemical Name: 2-(5-chloro-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)-N-cyclopropyl-1-benzothiophene-4-carboxamide trihydrochloride

Smiles: Cl.Cl.Cl.CN1CCN(CCCNC2=NC(=C(Cl)C=N2)C2=CC3=C(C=CC=C3C(=O)NC3CC3)S2)CC1

InChiKey: IEXCRLAGBWKVPW-UHFFFAOYSA-N

InChi: InChI=1S/C24H29ClN6OS.3ClH/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16;;;/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29);3*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.