Dihydrosanguinarine is an alkaloid and a metabolite of the alkaloid sanguinarine that has diverse biological activities, including anticancer, fungicidal, and antiprotozoal properties. It inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells when used at concentrations of 10, 20, and 30 µM. It also reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells. Dihydrosanguinarine inhibits spore germination of the phytopathogenic fungi B. cinerea and E. graminis in vitro. It has protective and curative effects against B. cinerea and E. graminis when applied as a spray to plants either before or after infection, respectively, at concentrations of 100 and 500 µg/ml. Dihydrosanguinarine is also effective against I. multifiliis infestation in S. curriculus with an LC50 value of 13.3 mg/L.
CAS Number: 3606-45-9
Molecular Weight: 333.34
Chemical Name: 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[220.127.116.11²,¹⁰.0⁴,⁸.0¹⁴,²².0¹⁷,²¹]tetracosa-1,3,8,10,12,14,16,21-octaene
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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