Cinobufotalin is a steroid glycoside that reduces SRC-3 protein levels in MCF-7 breast cancer cells, Na+/K+ pump activity, viability, and cell attachment of C7-MDCK cells, and expression of the epithelial-mesenchymal (EMT) markers E-cadherin, vimentin, ZEB1, and Slug in. Cinobufotalin is cytotoxic to A549, H460, and HTB-58 lung cancer cells. In vivo, Cinobufotalin reduces tumor volume and increases survival in an A549 mouse xenograft model.
CAS Number: 1108-68-5
Molecular Weight: 458.54
Chemical Name: (1R,2S,4R,5R,6R,7R,10S,11R,14S,16S)-14,16-dihydroxy-7,11-dimethyl-6-(2-oxo-2H-pyran-5-yl)-3-oxapentacyclo[188.8.131.52²,⁴.0²,⁷.0¹¹,¹⁶]octadecan-5-yl acetate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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