NS-1619


Catalog No. Size PriceQuantity
M8436-2 Solid 2 mg $90
M8436-10 Solid 10 mg $270

Description

NS1619 is a Bkca opener or large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. NS1619 pretreatment protects against shock-induced vascular hyporeactivity through PDZ-Rho GEF-RhoA-Rho kinase pathway in rats. NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA.NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle.

Product information

CAS Number: 153587-01-0

Molecular Weight: 362.23

Formula: C15H8F6N2O2

Chemical Name: 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one

Smiles: OC1=CC=C(C=C1N1C(=O)NC2=CC(=CC=C12)C(F)(F)F)C(F)(F)F

InChiKey: YLFMCMWKHSDUCT-UHFFFAOYSA-N

InChi: InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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