Description
Amikacin is an antibiotic used for a number of bacterial infections. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used for the treatment of multidrug-resistant tuberculosis. It is used either by injection into a vein or muscle. Amikacin is in the aminoglycoside family of medications. It works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to make protein.
Product information
CAS Number: 39831-55-5
Molecular Weight: 781.76
Formula: C22H47N5O21S2
Synonym:
Pierami
Amikacin bis(sulphate)
Amikin sulfate
BAY-416651 sulfate
Chemical Name: (S)-4-amino-N-((1R, 2S, 3S, 4R, 5S)-5-amino-2-((2S, 3R, 4S, 5S, 6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4-((2R, 3R, 4S, 5S, 6R)-6-(aminomethyl)-3, 4, 5-trihydroxytetrahydro-2H-pyran-2-yloxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide bis(sulfate)
Smiles: N[C@H]1C[C@@H](NC(=O)[C@@H](O)CCN)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](N)[C@H]2O)[C@@H](O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O.OS(O)(=O)=O.OS(O)(=O)=O
InChiKey: FXKSEJFHKVNEFI-GCZBSULCSA-N
InChi: InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Water: 10 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Umezawa H. Jpn J Antibiot, 1979, 32 Suppl, S1-S14.
- Gangadharam PR, et al. Antimicrob Agents Chemother, 1988, 32(9), 1400-1403.
- Xiong YQ, et al. Antimicrob Agents Chemother, 1997, 41(4), 823-826.
Products are for research use only. Not for human use.
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