K-Ras G12C-IN-3

Catalog No. Size PriceQuantity
M8513-2 Solid 2 mg $130
M8513-10 Solid 10 mg $390


K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.IC50 value:Target: K-ras G12C inhibitorFor more information, please see the following patent.Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereofBy Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.

Product information

CAS Number: 1629268-19-4

Molecular Weight: 453.75

Formula: C21H19Cl3N2O3

Chemical Name: 1-(4-{2',5',6-trichloro-4-methoxy-[1,1'-biphenyl]-3-carbonyl}piperazin-1-yl)prop-2-en-1-one

Smiles: COC1=CC(Cl)=C(C=C1C(=O)N1CCN(CC1)C(=O)C=C)C1=CC(Cl)=CC=C1Cl


InChi: InChI=1S/C21H19Cl3N2O3/c1-3-20(27)25-6-8-26(9-7-25)21(28)16-11-15(18(24)12-19(16)29-2)14-10-13(22)4-5-17(14)23/h3-5,10-12H,1,6-9H2,2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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