Description
BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). It attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. BMS 345541 also suppresses joint destruction in a mouse model of arthritis.
Product information
CAS Number: 547757-23-3
Molecular Weight: 291.78
Formula: C14H18ClN5
Synonym:
BMS345541 hydrochloride
BMS-345541 hydrochloride
BMS 345541 hydrochloride
Chemical Name: N1-{1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl}ethane-1,2-diamine hydrochloride
Smiles: Cl.CC1=CC2=C(C=C1)N=C(NCCN)C1=NC=C(C)N21
InChiKey: MIDKPVLYXNLFGZ-UHFFFAOYSA-N
InChi: InChI=1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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