Catalog No. Size PriceQuantity
M8584-2 Solid 2 mg $115
M8584-10 Solid 10 mg $345


ETP-46321 is a potent and orally bioavailable PI3K α, δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K-Ras(G12V) oncogenic mutation. Treatment with ETP-46321 resulted in significant tumor growth inhibition.

Product information

CAS Number: 1252594-99-2

Molecular Weight: 473.55

Formula: C20H27N9O3S


ETP 46321


Chemical Name: 5-{2-[(4-methanesulfonylpiperazin-1-yl)methyl]-8-(morpholin-4-yl)imidazo[1,2-a]pyrazin-6-yl}pyrimidin-2-amine

Smiles: CS(=O)(=O)N1CCN(CC2=CN3C=C(N=C(C3=N2)N2CCOCC2)C2=CN=C(N)N=C2)CC1


InChi: InChI=1S/C20H27N9O3S/c1-33(30,31)29-4-2-26(3-5-29)12-16-13-28-14-17(15-10-22-20(21)23-11-15)25-19(18(28)24-16)27-6-8-32-9-7-27/h10-11,13-14H,2-9,12H2,1H3,(H2,21,22,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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