ON 146040

Catalog No. Size PriceQuantity
M8586-2 Solid 2 mg $130
M8586-10 Solid 10 mg $390


ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50

Product information

CAS Number: 1404231-34-0

Molecular Weight: 489.55

Formula: C24H23N7O3S




Chemical Name: (7Z)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7-[(4-nitrophenyl)methylidene]-5H,6H,7H-pyrimido[4,5-b][1,4]thiazin-6-one

Smiles: CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC2S/C(=C\C3C=CC(=CC=3)[N+]([O-])=O)/C(=O)NC=2C=N1


InChi: InChI=1S/C24H23N7O3S/c1-29-10-12-30(13-11-29)18-8-4-17(5-9-18)26-24-25-15-20-23(28-24)35-21(22(32)27-20)14-16-2-6-19(7-3-16)31(33)34/h2-9,14-15H,10-13H2,1H3,(H,27,32)(H,25,26,28)/b21-14-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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