Description
Eluxadoline is an orally-active drug approved for the treatment of diarrhea and abdominal pain in individuals with diarrhea-predominant irritable bowel syndrome (IBS-D). Eluxadoline is a μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist that acts locally in the enteric nervous system, possibly decreasing adverse effects on the central nervous system. This product is discontinued (DEA Schedule IV).
Product information
CAS Number: 864821-90-9
Molecular Weight: 569.65
Formula: C32H35N5O5
Synonym:
JNJ-27018966
Chemical Name: 5-{[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)-N-[(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]propanamido]methyl}-2-methoxybenzoic acid
Smiles: C[C@@H](C1NC(=CN=1)C1C=CC=CC=1)N(CC1=CC(C(O)=O)=C(C=C1)OC)C(=O)[C@@H](N)CC1C(C)=CC(=CC=1C)C(N)=O
InChiKey: QFNHIDANIVGXPE-FNZWTVRRSA-N
InChi: InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Adler AI. NICE guidance on eluxadoline for treating irritable bowel syndrome with diarrhoea. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):779-780.
- Shahid Z, Packard E, Groff A, Jain R. Eluxadoline-induced pancreatitis occurring in an adult man without a prior cholecystectomy. BMJ Case Rep. 2019 Aug 28;12(8).
- Lai SW. Safety of Eluxadoline Use. Am J Gastroenterol. 2019 Jul;114(7):1176-1177.
Products are for research use only. Not for human use.
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