LY-411575 isomer 3, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50= 0.078 nM/0.082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0.41 nM).
CAS Number: 2070009-28-6
Molecular Weight: 479.48
LY411575 isomer 3
LY 411575 isomer 3
Chemical Name: (2R)-2-[(2R)-2-(3, 5-difluorophenyl)-2-hydroxyacetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[18.104.22.168, ]pentadeca-1(11), 2(7), 3, 5, 12, 14-hexaen-10-yl]propanamide
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
- Fauq AH, et al. A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6392-5. Epub 2007 Aug 30.
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