Eflornithine


Catalog No. Size PriceQuantity
M8760-2 Solid 2 mg $80
M8760-10 Solid 10 mg $240

Description

Eflornithine, also known as Difluoromethylornithine, is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells.

Product information

CAS Number: 70052-12-9

Molecular Weight: 182.17

Formula: C6H12F2N2O2

Synonym:

DFMO

MDL71782

RMI71782

α-difluoromethylornithine

Vaniqa

Chemical Name: 2,5-diamino-2-(difluoromethyl)pentanoic acid

Smiles: NCCCC(N)(C(F)F)C(O)=O

InChiKey: VLCYCQAOQCDTCN-UHFFFAOYSA-N

InChi: InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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