Catalog No. Size PriceQuantity
M8772-2 Solid 2 mg $370
M8772-10 Solid 10 mg $1,480


Corynoxeine is an alkaloid that has been found in Uncaria and has diverse biological activities. It inhibits LPS-induced production of nitric oxide in primary rat microglia. Corynoxeine inhibits PDGF-BB-induced ERK1/2 activation in, and proliferation of, rat aortic vascular smooth muscle cells. It inhibits histamine release from LAD 2 mast cells induced by compound 48/80 when used at concentrations ranging from 25 to 200 µM. In vivo, corynoxeine reduces compound 48/80-induced local anaphylaxis and mast cell degranulation in mouse hind paws. Corynoxeine also reduces methamphetamine-induced hyperlocomotion in mice.

Product information

CAS Number: 630-94-4

Molecular Weight: 382.45

Formula: C22H26N2O4

Chemical Name: methyl (2E)-2-[(3R,6'R,7'S,8'aS)-6'-ethenyl-2-oxo-1,2,3',5',6',7',8',8'a-octahydro-2'H-spiro[indole-3,1'-indolizin]-7'-yl]-3-methoxyprop-2-enoate

Smiles: CO/C=C(\[C@H]1C[C@@H]2N(C[C@@H]1C=C)CC[C@]12C2=CC=CC=C2NC1=O)/C(=O)OC


InChi: InChI=1S/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8,13-15,19H,1,9-12H2,2-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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