Corynoxeine is an alkaloid that has been found in Uncaria and has diverse biological activities. It inhibits LPS-induced production of nitric oxide in primary rat microglia. Corynoxeine inhibits PDGF-BB-induced ERK1/2 activation in, and proliferation of, rat aortic vascular smooth muscle cells. It inhibits histamine release from LAD 2 mast cells induced by compound 48/80 when used at concentrations ranging from 25 to 200 µM. In vivo, corynoxeine reduces compound 48/80-induced local anaphylaxis and mast cell degranulation in mouse hind paws. Corynoxeine also reduces methamphetamine-induced hyperlocomotion in mice.
CAS Number: 630-94-4
Molecular Weight: 382.45
Chemical Name: methyl (2E)-2-[(3R,6'R,7'S,8'aS)-6'-ethenyl-2-oxo-1,2,3',5',6',7',8',8'a-octahydro-2'H-spiro[indole-3,1'-indolizin]-7'-yl]-3-methoxyprop-2-enoate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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