CBB1007 pentahydrochloride


Catalog No. Size PriceQuantity
M8846-2 Contact sales@xcessbio.com for quotation $100
M8846-10 Contact sales@xcessbio.com for quotation $100

Description

CBB1007 is a potent and selective Lysine-specific demethylase 1 (LSD1) inhibitor.

Product information

CAS Number: 2070014-96-7

Molecular Weight: 716.91

Formula: C27H39Cl5N8O4

Synonym:

CBB-1007 hydrochloride

Chemical Name: methyl 3-[4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl]-5-[(4-carbamimidoylpiperazin-1-yl)methyl]benzoate pentahydrochloride

Smiles: Cl.Cl.Cl.Cl.Cl.COC(=O)C1=CC(=CC(CN2CCN(CC2)C(N)=N)=C1)C(=O)N1CCN(CC1)C(=O)C1C=CC(=CC=1)C(N)=N

InChiKey: FBXRLNJMTYEDJA-UHFFFAOYSA-N

InChi: InChI=1S/C27H34N8O4.5ClH/c1-39-26(38)22-15-18(17-32-6-8-35(9-7-32)27(30)31)14-21(16-22)25(37)34-12-10-33(11-13-34)24(36)20-4-2-19(3-5-20)23(28)29;;;;;/h2-5,14-16H,6-13,17H2,1H3,(H3,28,29)(H3,30,31);5*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Singh AK, Chandra N, Bapat SA. Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. Clin Cancer Res. 2015 Nov 15;21(22):5151-63.
  2. Li A, He Y, Sun S, Cai C, Li H. Lysine-specific demethylase 1 inhibitors protect cochlear spiral ganglion neurons against cisplatin-induced damage. Neuroreport. 2015 Jun 17;26(9):539-47.
  3. Xiong Y, Wang E, Huang Y, Guo X, Yu Y, Du Q, Ding X, Sun Y. Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation. Stem Cell Rev. 2016 Jun;12(3):298-304.

Products are for research use only. Not for human use.

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