Description
FLX925, also known as AMG-925, is a potent and selective type 1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 occurring with quizartinib or sorafenib treatment (FLX925 IC50: MOLM13ITD, 15 nM; MOLM13ITD/D835, 28 nM; MV4-11ITD, 16 nM; MV4-11ITD/D835, 19 nM; MV4-11ITD/N841, 16 nM; MV4-11ITD/F691, 73 nM).
Product information
CAS Number: 1401033-86-0
Molecular Weight: 471.55
Formula: C26H29N7O2
Synonym:
AMG-925
AMG925
Chemical Name: 2-hydroxy-1-(2-{[8-(4-methylcyclohexyl)-4,6,8,11-tetraazatricyclo[7.4.0.0²,⁷]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino}-5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl)ethan-1-one
Smiles: CC1CCC(CC1)N1C2=NC(NC3=CC=C4CN(CCC4=N3)C(=O)CO)=NC=C2C2=CC=NC=C12
InChiKey: BBUVDDPUURMFOX-UHFFFAOYSA-N
InChi: InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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