Cinepazide


Catalog No. Size PriceQuantity
M8972-2 Contact sales@xcessbio.com for quotation $100
M8972-10 Contact sales@xcessbio.com for quotation $100

Description

Cinepazide is a vasodilator used for the treatment of cardiovascular, cerebrovascular, and peripheral vascular diseases. Cinepazide acts as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker.

Product information

CAS Number: 23887-46-9

Molecular Weight: 417.50

Formula: C22H31N3O5

Chemical Name: 1-{4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Smiles: COC1C=C(C=C(OC)C=1OC)C=CC(=O)N1CCN(CC(=O)N2CCCC2)CC1

InChiKey: RCUDFXMNPQNBDU-VOTSOKGWSA-N

InChi: InChI=1S/C22H31N3O5/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24/h6-7,14-15H,4-5,8-13,16H2,1-3H3/b7-6+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cinepazide (intravenous injection; 30 mg/kg) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, while cinnarizine reduces their vasodilator effects. Cinepazide (intravertebral injection; 1-10 mg/kg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by Aminophylline (HY-B0140) in dogs.

References:

  1. Akashi, A., et al., [Cardiovascular pharmacology of cinepazide, a new cerebral vasodilator (author's transl)]. Nihon Yakurigaku Zasshi, 1979. 75(5): p. 507-16.
  2. Jonathan G Swoboda, et al. Small molecule mediated proliferation of primary retinal pigment epithelial cells. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.

Products are for research use only. Not for human use.

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