Description
Azeliragon free base, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for Alzheimer's disease and cerebral amyloid angiopathy.
Product information
CAS Number: 50-65-7
Molecular Weight: 327.12
Formula: C13H8Cl2N2O4
Synonym:
Niclocide
BAY2353
Cestocid
Sagimid
Yomesan
Chemical Name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Smiles: OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)N(=O)=O
InChiKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
InChi: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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