β-NF-JQ1

β-NF-JQ1 is a PROTAC that recruits AhR E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.

Product information

CAS Number: 2380000-55-3

Molecular Weight: 816.36

Formula: C45H42ClN5O6S

Chemical Name: 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[2-(2-{2-[(4-{1-oxo-1H-benzo[f]chromen-3-yl}phenyl)methoxy]ethoxy}ethoxy)ethyl]acetamide

Smiles: CC1=NN=C2[C@H](CC(=O)NCCOCCOCCOCC3C=CC(=CC=3)C3=CC(=O)C4C5=CC=CC=C5C=CC=4O3)N=C(C3=C(SC(C)=C3C)N12)C1C=CC(Cl)=CC=1

InChiKey: OZFKLXDOAZGVSV-BHVANESWSA-N

InChi: InChI=1S/C45H42ClN5O6S/c1-27-28(2)58-45-41(27)43(33-12-15-34(46)16-13-33)48-36(44-50-49-29(3)51(44)45)24-40(53)47-18-19-54-20-21-55-22-23-56-26-30-8-10-32(11-9-30)39-25-37(52)42-35-7-5-4-6-31(35)14-17-38(42)57-39/h4-17,25,36H,18-24,26H2,1-3H3,(H,47,53)/t36-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.