β-cyano-L-Alanine

β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

Product information

CAS Number: 6232-19-5

Molecular Weight: 114.10

Formula: C4H6N2O2

Synonym:

Beta-cyano-l-alanine

Chemical Name: (2S)-2-amino-3-cyanopropanoic acid

Smiles: N[C@@H](CC#N)C(O)=O

InChiKey: BXRLWGXPSRYJDZ-VKHMYHEASA-N

InChi: InChI=1S/C4H6N2O2/c5-2-1-3(6)4(7)8/h3H,1,6H2,(H,7,8)/t3-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 20.83 mg/mL (182.56 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

β-cyano-L-Alanine (intraperitoneally; 50 mg/kg) abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

References:

1. Piotrowski M, et al. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase.J Med Chem. J Biol Chem. 2001 Jan 26;276(4):2616-21.
2. McCarter KD, et al. Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine γ-lyase. Alcohol. 2019 May;76:81-89.

Products are for research use only. Not for human use.