β-Interleukin I (163-171), human

β-Interleukin I (163-171), human(C39H64N12O19), a peptide with the sequence Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys, MW= 1005. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). Interleukin 1 alpha and interleukin 1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Figure1 Formula of b-Interleukin I (163-171), human Figure2 Structure of b-Interleukin I Ref: 1. Contassot E, Beer HD, French LE (2012). "Interleukin-1, inflammasomes, autoinflammation and the skin". 142: w13590 2. Matzinger P (2012). "The evolution of the danget theory. Interview by Lauren Constable, Commissioning Editor". 8 (4): 311-7. 3. Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011). "Role of the inflammasome, IL-1β, and IL-18 inbacterial infections". 11: 2037-50.

Product information

CAS Number: 106021-96-9

Molecular Weight: 1004.99

Formula: C39H64N12O19

Chemical Name: 6-amino-2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-methylbutanamido)-4-carbamoylbutanamido]acetamido}-4-carboxybutanamido)-4-carboxybutanamido]-3-hydroxypropanamido}-3-carbamoylpropanamido)-3-carboxypropanamido]hexanoic acid

Smiles: CC(C)C(N)C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(O)=O

InChiKey: NIXBZDOQHRZFDR-UHFFFAOYSA-N

InChi: InChI=1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.