2', 3', 5'-triacetyl-5-Azacytidine

2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration . 5-Azacytidine is an inhibitor of DNA methyltransferase . The DNA methyltransferase belongs to a family of enzymes involved in catalyzing the transfer of a methyl group to DNA. DNA methylation has been implicated in regulating gene expression in normal and malignant cells . In vivo: In CD-1 mice, oral administration of TAC for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. TAC inhibited global DNA methylation in the spleen and gut. In an in vivo L1210 leukemia model, TAC exhibited antineoplastic activity .

Product information

CAS Number: 10302-78-0

Molecular Weight: 370.31

Formula: C14H18N4O8

Chemical Name: [(2R,3R,4R,5R)-3,4-bis(acetyloxy)-5-(4-amino-2-oxo-1,2-dihydro-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate

Smiles: CC(=O)O[C@@H]1[C@@H](COC(C)=O)O[C@H]([C@@H]1OC(C)=O)N1C=NC(N)=NC1=O

InChiKey: OTQJVHISAFFLMA-DDHJBXDOSA-N

InChi: InChI=1S/C14H18N4O8/c1-6(19)23-4-9-10(24-7(2)20)11(25-8(3)21)12(26-9)18-5-16-13(15)17-14(18)22/h5,9-12H,4H2,1-3H3,(H2,15,17,22)/t9-,10-,11-,12-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.