Dicloxacillin Sodium hydrate

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus.

Product information

CAS Number: 13412-64-1

Molecular Weight: 510.32

Formula: C19H18Cl2N3NaO6S

Synonym:

Dicloxacillin sodium salt monohydrate

Chemical Name: sodium (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-amido]-5-hydrogenio-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate

Smiles: O.[Na+].CC1ON=C(C=1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)C1C(Cl)=CC=CC=1Cl

InChiKey: SIGZQNJITOWQEF-VICXVTCVSA-M

InChi: InChI=1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 25 mg/mL (48.99 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively.

In Vivo:

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied.

References:

1. Jusko WJ, et al. Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis. Pediatrics. 1975 Dec;56(6):1038-44.
2. Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25.
3. Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun;54(6):2391-400.

Products are for research use only. Not for human use.