BNC375

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375 exhibits good CNS-drug like properties and clinical candidate potential. .

Product information

CAS Number: 1557240-80-8

Molecular Weight: 394.92

Formula: C19H23ClN2O3S

Chemical Name: 4-[(1R,3R)-3-{[(5-chloro-2-methoxyphenyl)amino]methyl}-2,2-dimethylcyclopropyl]benzene-1-sulfonamide

Smiles: COC1=CC=C(Cl)C=C1NC[C@@H]1[C@@H](C2C=CC(=CC=2)S(N)(=O)=O)C1(C)C

InChiKey: LWWDCTBUJUEFDE-CRAIPNDOSA-N

InChi: InChI=1S/C19H23ClN2O3S/c1-19(2)15(11-22-16-10-13(20)6-9-17(16)25-3)18(19)12-4-7-14(8-5-12)26(21,23)24/h4-10,15,18,22H,11H2,1-3H3,(H2,21,23,24)/t15-,18-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 83.33 mg/mL (211.00 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization.

In Vivo:

BNC375 (0.003-10.0 mg/kg, administered orally) exhibits the MED of 0.03 mg/kg, and achieves full reversal of the Scopolamine-induced impairment at 1.0 mg/kg in mouse T-maze model. BNC375 exhibits the plasm half-life (t1/2) of 1.2 h.

References:

1. Andrew J. Harvey, et al. Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. Cite This:ACS Med. Chem. Lett.2019105754-760.

Products are for research use only. Not for human use.