SRI-37330 HCl

SRI-37330 hydrochloride is a novel inhibitor of TXNIP expression, decreasing glucagon secretion and action and blocking hepatic glucose output, reversing obesity- and STZ-induced diabetes and hepatic steatosis.

Product information

CAS Number: 2322245-49-6

Molecular Weight: 424.87

Formula: C16H20ClF3N4O2S

Chemical Name: N-((1-(6-(trifluoromethyl)quinazolin-4-yl)piperidin-3-yl)methyl)methanesulfonamide hydrochloride

Smiles: Cl.CS(=O)(=O)NCC1CN(CCC1)C1=NC=NC2=CC=C(C=C21)C(F)(F)F

InChiKey: SIWGSSRKYJTJTF-UHFFFAOYSA-N

InChi: InChI=1S/C16H19F3N4O2S.ClH/c1-26(24,25)22-8-11-3-2-6-23(9-11)15-13-7-12(16(17,18)19)4-5-14(13)20-10-21-15;/h4-5,7,10-11,22H,2-3,6,8-9H2,1H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Thielen LA, Chen J, Jing G, Moukha-Chafiq O, Xu G, Jo S, Grayson TB, Lu B, Li P, Augelli-Szafran CE, Suto MJ, Kanke M, Sethupathy P, Kim JK, Shalev A. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8. doi: 10.1016/j.cmet.2020.07.002. Epub 2020 Jul 28. PMID: 32726606; PMCID: PMC7501995.
2. Thielen LA, Chen J, Jing G, Moukha-Chafiq O, Xu G, Jo S, Grayson TB, Lu B, Li P, Augelli-Szafran CE, Suto MJ, Kanke M, Sethupathy P, Kim JK, Shalev A. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8. doi: 10.1016/j.cmet.2020.07.002. Epub 2020 Jul 28. PMID: 32726606; PMCID: PMC7501995.

Products are for research use only. Not for human use.