Kushenol K

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2.

Product information

CAS Number: 101236-49-1

Molecular Weight: 472.53

Formula: C26H32O8

Chemical Name: 2-(2,4-dihydroxyphenyl)-3,7-dihydroxy-8-[5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl]-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

Smiles: CC(=C)C(CC1=C2OC(C(O)C(=O)C2=C(C=C1O)OC)C1=CC=C(O)C=C1O)CCC(C)(C)O

InChiKey: YWHHRFNOJTVNBI-UHFFFAOYSA-N

InChi: InChI=1S/C26H32O8/c1-13(2)14(8-9-26(3,4)32)10-17-19(29)12-20(33-5)21-22(30)23(31)25(34-24(17)21)16-7-6-15(27)11-18(16)28/h6-7,11-12,14,23,25,27-29,31-32H,1,8-10H2,2-5H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%.

Products are for research use only. Not for human use.