VH 032 amide-PEG5-acid

VH 032 amide-PEG5-acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development. It incorporates an E3 ligase ligand plus a PEG5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. It is part of a range of functionalized tool molecules for PROTAC R&D.

Product information

CAS Number: 2172820-14-1

Molecular Weight: 750.90

Formula: C36H54N4O11S

Synonym:

E3 Ligase Ligand-Linker Conjugates 58

BCP33436

(S,R,S)-AHPC-PEG5-COOH

2172820-14-1

SCHEMBL19786337

EX-A3940

HY-130271

CS-0106354

VH032-PEG5-COOH

VHL Ligand-Linker Conjugates 16

[2-[2-[2-[2-[3-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Chemical Name: [2-[2-[2-[2-[3-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOC(C)C(O)=O)C(C)(C)C)=CC=1

InChiKey: KEVFVBURAAZURM-ZAPNVNOBSA-N

InChi: InChI=1S/C36H54N4O11S/c1-24-31(52-23-38-24)27-8-6-26(7-9-27)21-37-33(43)29-20-28(41)22-40(29)34(44)32(36(3,4)5)39-30(42)10-11-47-12-13-48-14-15-49-16-17-50-18-19-51-25(2)35(45)46/h6-9,23,25,28-29,32,41H,10-22H2,1-5H3,(H,37,43)(H,39,42)(H,45,46)/t25?,28-,29+,32-/m1/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

Products are for research use only. Not for human use.