(32-Carbonyl)-RMC-5552

(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2).

Product information

CAS Number: 2382768-55-8

Molecular Weight: 879.96

Formula: C42H57N9O12

Chemical Name: (1R, 2R, 4S)-4-[(2R)-2-[(1R, 9S, 12S, 15R, 18R, 19R, 21R, 23S, 30S, 32S, 35R)-1, 18-dihydroxy-19, 30-dimethoxy-15, 17, 21, 23, 29, 35-hexamethyl-2, 3, 10, 14, 20-pentaoxo-11, 36-dioxa-4-azatricyclo[30.3.1.0, ]hexatriaconta-16, 24, 26, 28-tetraen-12-yl]propyl]-2-methoxycyclohexyl N-[27-(6-{[4-amino-3-(2-amino-1, 3-benzoxazol-5-yl)-1H-pyrazolo[3, 4-d]pyrimidin-1-yl]methyl}-1, 2, 3, 4-tetrahydroisoquinolin-2-yl)-27-oxo-3, 6, 9, 12, 15, 18, 21, 24-octaoxaheptacosan-1-yl]carbamate

Smiles: NC1=NC2=CC(=CC=C2O1)C1=NN(CC2=CC3CCN(CC=3C=C2)C(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O)=O)C2=NC=NC(N)=C12

InChiKey: KFRKQPJGGQSJKC-UHFFFAOYSA-N

InChi: InChI=1S/C42H57N9O12/c43-39-37-38(32-3-4-35-34(26-32)48-41(44)63-35)49-51(40(37)47-29-46-39)27-30-1-2-33-28-50(8-5-31(33)25-30)36(52)6-9-55-11-13-57-15-17-59-19-21-61-23-24-62-22-20-60-18-16-58-14-12-56-10-7-45-42(53)54/h1-4,25-26,29,45H,5-24,27-28H2,(H2,44,48)(H,53,54)(H2,43,46,47)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.

Products are for research use only. Not for human use.