Description
CVN424 is an orally active and selective GPR6 inverse agonist with a EC50 of 9.4 nM and an EC50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research.
Product information
CAS Number: 2254706-21-1
Molecular Weight: 473.52
Formula: C24H29F2N5O3
Chemical Name: 1-{2-[4-(2, 4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-5H, 6H, 7H, 8H-pyrido[3, 4-b]pyrazin-6-yl}ethan-1-one
Smiles: CC(=O)N1CC2=NC(N[C@H]3COCC3)=C(N=C2CC1)N1CCC(CC1)OC1=CC=C(F)C=C1F
InChiKey: HSWVJQBEXRKOBZ-QGZVFWFLSA-N
InChi: InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CVN424 (Compound 6i) has 265 fold and 68 fold selectivities over GPR3 and GPR12.
Products are for research use only. Not for human use.
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