CV-6209

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, with IC50 values of 75 and 170 nM, respectively. CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.

Product information

CAS Number: 100488-87-7

Molecular Weight: 642.31

Formula: C34H60ClN3O6

Synonym:

[2-methoxy-3-(octadecylcarbamoyloxy)propyl] N-acetyl-N-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamate

Chemical Name: [3-[acetyl-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamoyl]oxy-2-methoxypropyl] N-octadecylcarbamate

Smiles: [Cl-].CC(=O)N(CC1=CC=CC=[N+]1CC)C(=O)OCC(COC(=O)NCCCCCCCCCCCCCCCCCC)OC

InChiKey: APUCCVGQZPNXIO-UHFFFAOYSA-N

InChi: InChI=1S/C34H59N3O6.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2;/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Iwao Y, Takano T, Taneike I, Reva I, Isobe H, Zhang HM, Nishiyama A, Yamamoto T. Anti-Helicobacter pylori actions of CV-6209, a platelet-activating factor receptor antagonist. J Gen Appl Microbiol. 2013;59(2):147-52. PubMed PMID: 23759868.
2. Qayumi KA, English JC, Feeley EJ, Poostizadeh A, Nikbakht-Sangari M. A new platelet-activating factor antagonist (CV-6209) in preservation of heart and lung for transplantation. Cardiovasc Drugs Ther. 1997 Dec;11(6):777-85. PubMed PMID: 9512873.
3. Gupta JB, Prasad M, Kalra J, Prasad K. Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. Angiology. 1994 Jan;45(1):25-36. PubMed PMID: 8285381.

Products are for research use only. Not for human use.