Ceapin-A7

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

Product information

CAS Number: 2323027-38-7

Molecular Weight: 470.32

Formula: C20H12F6N4O3

Chemical Name: N-(1-{[2,4-bis(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide

Smiles: O=C(NC1C=NN(CC2=CC=C(C=C2C(F)(F)F)C(F)(F)F)C=1)C1C=C(ON=1)C1=CC=CO1

InChiKey: UJTDYOXTXGBHEG-UHFFFAOYSA-N

InChi: InChI=1S/C20H12F6N4O3/c21-19(22,23)12-4-3-11(14(6-12)20(24,25)26)9-30-10-13(8-27-30)28-18(31)15-7-17(33-29-15)16-2-1-5-32-16/h1-8,10H,9H2,(H,28,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (212.62 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Ceapin-A7 sensitizes cells to ER stress. Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β.

Products are for research use only. Not for human use.