PHGDH-IN-2

PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells.

Product information

Molecular Weight: 420.48

Formula: C22H20N4O3S

Smiles: CN1C(=CC2=CC=CC=C12)C(=O)NC1=CC(=CC=C1)NS(=O)(=O)C1=CC=C(N)C=C1

InChiKey: WKJRUZSZIGPOBZ-UHFFFAOYSA-N

InChi: InChI=1S/C22H20N4O3S/c1-26-20-8-3-2-5-15(20)13-21(26)22(27)24-17-6-4-7-18(14-17)25-30(28,29)19-11-9-16(23)10-12-19/h2-14,25H,23H2,1H3,(H,24,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhang FM,et al. Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study. Bioorg Chem. 2022, 121:105705.

Products are for research use only. Not for human use.