Phosphodiesterases (PDEs) are metallohydrolases that control the concentration of second messengers cyclic adenosine monophosphate and cyclic guanosine monophosphate. Cyclic nucleotides are critical intracellular signaling molecules that are required for the proper function of the brain. All neurons express PDEs, and PDE inhibition represents a mechanism through which it could be possible to precisely modulate neuronal activity. The interest for PDEs as targets continues to grow within therapies to treat CNS diseases, particularly for cognitive dysfunction and neuropsychiatric diseases.
GSK256066, PDE4 inhibitor
From $140
IBMX
From $80
Ibudilast
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Icariin
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Irsogladine
From $80
Irsogladine maleate
From $75
Levosimendan
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LMN75224
From $148
Milrinone
From $75
Mirodenafil
From $130
Mirodenafil dihydrochloride
From $130
Moracin M
$100
Nortadalafil
From $100
NVR 3-778
From $735
Oglemilast
From $100
Olprinone
From $100
Olprinone Hydrochloride
From $95
PDE-9 inhibitor
From $130
PDE1-IN-1
From $125
PDE1-IN-1 phosphate
From $125
PDE10-IN-1
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Pentoxifylline
From $80