Phosphodiesterases (PDEs) are metallohydrolases that control the concentration of second messengers cyclic adenosine monophosphate and cyclic guanosine monophosphate. Cyclic nucleotides are critical intracellular signaling molecules that are required for the proper function of the brain. All neurons express PDEs, and PDE inhibition represents a mechanism through which it could be possible to precisely modulate neuronal activity. The interest for PDEs as targets continues to grow within therapies to treat CNS diseases, particularly for cognitive dysfunction and neuropsychiatric diseases.
PF-04447943
From $180
PF-07038124
$100
PF-2545920
From $120
PF-8380
From $90
Pimobendan
From $75
Pimobendan Hydrochloride
From $105
Roflumilast
From $80
Roflumilast N-oxide
From $80
Rolipram
From $130
Sildenafil
From $75
Sildenafil Citrate
From $96
Sp-cAMPS
From $270
Sp-cAMPS sodium salt
From $270
Tadalafil
From $80
TAK-063
From $90
Theophylline
From $80
Vardenafil
$100
Vesnarinone
From $96
Vinpocetine
From $75
VU0155041 sodium
$100
Zardaverine
From $95