Description
K-Ras G12C-IN-2 is an irreversible covalent K-Ras G12C inhibitor.
Product information
CAS Number: 1629267-75-9
Molecular Weight: 418.92
Formula: C21H27ClN4O3
Chemical Name: 1-[3-(4-{2-[(4-chloro-5-cyclopropyl-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]prop-2-en-1-one
Smiles: C=CC(=O)N1CC(C1)N1CCN(CC1)C(=O)CNC1=CC(C2CC2)=C(Cl)C=C1O
InChiKey: LTHUJAPYGTUVMD-UHFFFAOYSA-N
InChi: InChI=1S/C21H27ClN4O3/c1-2-20(28)26-12-15(13-26)24-5-7-25(8-6-24)21(29)11-23-18-9-16(14-3-4-14)17(22)10-19(18)27/h2,9-10,14-15,23,27H,1,3-8,11-13H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Pingda Ren, et al. Covalent inhibitors of kras g12c. WO2014152588A1
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