CH7057288


Catalog No. Size PriceQuantity
M19679-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CH7057288 is a potent and selective TRK inhibitor.

Product information

CAS Number: 2095616-82-1

Molecular Weight: 569.67

Formula: C32H31N3O5S

Chemical Name: N-tert-butyl-2-(2-{5-methanesulfonamido-2,2-dimethyl-9-oxo-17-oxatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),3,5,7,11,13,15-heptaen-14-yl}ethynyl)-6-methylpyridine-4-carboxamide

Smiles: CC(C)(C)NC(=O)C1C=C(C#CC2C=C3OC4=C(C(=O)C5=CC=C(C=C5C4(C)C)NS(C)(=O)=O)C3=CC=2)N=C(C)C=1

InChiKey: DCGOHGQJHJXBGW-UHFFFAOYSA-N

InChi: InChI=1S/C32H31N3O5S/c1-18-14-20(30(37)34-31(2,3)4)16-21(33-18)10-8-19-9-12-24-26(15-19)40-29-27(24)28(36)23-13-11-22(35-41(7,38)39)17-25(23)32(29,5)6/h9,11-17,35H,1-7H3,(H,34,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 34 mg/mL (59.68 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed