GNF-5837


Catalog No. Size PriceQuantity
M9916-2 Solid 2 mg $85
M9916-10 Solid 10 mg $255

Description

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.

Product information

CAS Number: 1033769-28-6

Molecular Weight: 535.49

Formula: C28H21F4N5O2

Chemical Name: 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-(4-methyl-3-{[(3Z)-2-oxo-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-6-yl]amino}phenyl)urea

Smiles: CC1=CC=C(C=C1NC1=CC2NC(=O)/C(=C\C3=CC=CN3)/C=2C=C1)NC(=O)NC1=CC(=CC=C1F)C(F)(F)F

InChiKey: YYDUWLSETXNJJT-MTJSOVHGSA-N

InChi: InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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