CRISPR Editing Tool Box


Catalog No. size PriceQuantity
LI30010-2S 2 mg solid $499

Description

Product Information

A very useful small molecule collection to improve CRISPR editing efficacy, 2 mg solid each for the following compounds:


  • SCR7: a NHEJ inhibitor promotes the efficiency of HDR 4–5-fold for CRISPR editing in both human and mouse cell lines.
  • RS-1a RAD51-Stimulatory compound enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. 
  • (Z)-4-Hydroxytamoxifen: a previously characterised as an Estrogen Receptor antagonist and now found to improve genome-editing specificity. 
  • L755,507: a β3 adrenergic receptor partial agonist enhances CRISPR-mediated HDR efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. 
  • Azidothymidine (AZT): a reverse transcriptase inhibitor enhances CRISPR-mediated sequence-specific gene knockout via NHEJ in human induced pluripotent stem cells (iPSCs) and other cell types. 
  • Nocodazole enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.
  • ME0328 enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.

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