N-Me-L-Ala-maytansinol


Catalog No. Size PriceQuantity
M12159-2 Contact sales@xcessbio.com for quotation $100
M12159-10 Contact sales@xcessbio.com for quotation $100

Description

N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC).

Product information

CAS Number: 77668-69-0

Molecular Weight: 650.16

Formula: C32H44ClN3O9

Chemical Name: (1S, 2R, 3S, 5S, 6S, 20R, 21S)-11-chloro-21-hydroxy-12, 20-dimethoxy-2, 5, 9, 16-tetramethyl-8, 23-dioxo-4, 24-dioxa-9, 22-diazatetracyclo[19.3.1.1, .0, ]hexacosa-10, 12, 14(26), 16, 18-pentaen-6-yl (2S)-2-(methylamino)propanoate

Smiles: C[C@@]12O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1=CC(=C(Cl)C(=C1)OC)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)NC)OC |c:19,t:17|

InChiKey: ANHBJISROJTYCJ-VQFNSVNYSA-N

InChi: InChI=1S/C32H44ClN3O9/c1-17-10-9-11-24(42-8)32(40)16-23(43-30(39)35-32)18(2)28-31(4,45-28)25(44-29(38)19(3)34-5)15-26(37)36(6)21-13-20(12-17)14-22(41-7)27(21)33/h9-11,13-14,18-19,23-25,28,34,40H,12,15-16H2,1-8H3,(H,35,39)/b11-9-,17-10-/t18-,19+,23+,24-,25+,28+,31+,32+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Nittoli T, et al. Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279.

Products are for research use only. Not for human use.

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