A-192621


Catalog No. Size PriceQuantity
M12620-2 Contact sales@xcessbio.com for quotation $100
M12620-10 Contact sales@xcessbio.com for quotation $100

Description

A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level.

Product information

CAS Number: 195529-54-5

Molecular Weight: 558.66

Formula: C33H38N2O6

Chemical Name: (2R, 3R, 4S)-4-(2H-1, 3-benzodioxol-5-yl)-1-{[(2, 6-diethylphenyl)carbamoyl]methyl}-2-(4-propoxyphenyl)pyrrolidine-3-carboxylic acid

Smiles: CCC1C=CC=C(CC)C=1NC(=O)CN1C[C@@H]([C@H]([C@@H]1C1C=CC(=CC=1)OCCC)C(O)=O)C1C=C2OCOC2=CC=1

InChiKey: LQEHCKYYIXQEBM-FUKIBTTHSA-N

InChi: InChI=1S/C33H38N2O6/c1-4-16-39-25-13-10-23(11-14-25)32-30(33(37)38)26(24-12-15-27-28(17-24)41-20-40-27)18-35(32)19-29(36)34-31-21(5-2)8-7-9-22(31)6-3/h7-15,17,26,30,32H,4-6,16,18-20H2,1-3H3,(H,34,36)(H,37,38)/t26-,30-,32+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Chaowei Ren, et al. Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile. J. Med. Chem. 2021, June 17; doi: 10.1021/acs.jmedchem.1c00373

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed