DL-Glutamine

DL-Glutamine is used for biochemical research and drug synthesis.

Product information

CAS Number: 6899-04-3

Molecular Weight: 146.14

Formula: C5H10N2O3

Synonym:

(±)-Glutamine; DL-Gl

Chemical Name: 2-amino-4-carbamoylbutanoic acid

Smiles: NC(=O)CCC(N)C(O)=O

InChiKey: ZDXPYRJPNDTMRX-UHFFFAOYSA-N

InChi: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 33.33 mg/mL (228.07 mM; Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DL-Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, as well as providing a source of carbons for oxidation in some cell. Glutamine has been reported to enhance many functional parameters of immune cells such as T-cell proliferation, B-lymphocyte differentiation, macrophage phagocytosis, antigen presentation and cytokine production plus neutrophil superoxide production and apoptosis. Glutamine itself may act as a key precursor for nucleic acids and nucleotides in glutamine-consuming cells, but in many physiological circumstances acts to provide glutamate, which appears to promote a wider array of metabolic functions compared to glutamine.

In Vivo:

DL-Glutamate is the most abundant intracellular amino acid whereas L-glutamine is the most abundant extracellular amino acid in vivo. Glutamine metabolism is zoned in the liver so that glutamine is taken up by the periportal cells of the liver in which there is a relatively high glutaminase activity and the ammonia produced directed towards carbamoyl phosphate synthesis.

References:

1. Newsholme P, et al. Cell Biochem Funct. 2003, 21(1):1-9.

Products are for research use only. Not for human use.