Bethanechol


Catalog No. Size PriceQuantity
M13376-2 2mg solid $80
M13376-10 10mg solid $240

Description

Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.

Product information

CAS Number: 674-38-4

Molecular Weight: 161.22

Formula: C7H17N2O2

Synonym:

Carbamyl-β-methylcholine

Chemical Name: 1-(trimethylazaniumyl)propan-2-yl carbamate

Smiles: CC(C[N+](C)(C)C)OC(N)=O

InChiKey: NZUPCNDJBJXXRF-UHFFFAOYSA-O

InChi: InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials.

In Vivo:

Bethanechol (2-12 mg/kg; i.p.) induces drinking and increased urine output of rats in a dose-dependent fashion.

References:

  1. Inderbir S. Padda, et al. Bethanechol. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
  2. Julia Yuen Hang Liu, et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G97-G107.
  3. M J Fregly, et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17(4):727-32.

Products are for research use only. Not for human use.

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